Vascular complications were defined Elafibranor by the Valve Academic Research Consortium (VARC) criteria. The ratio of the sheath outer diameter (in millimeters) to the minimal femoral artery diameter (in millimeters) defined the sheath to femoral

artery ratio (SFAR).\n\nResults In our cohort of elderly patients (83.3 +/- 5.9 years), the logistic Euro Score was 25.8% +/- 11.9%. The Edwards valve was used in 102 cases (18- to 24-F) and the Core Valve in 27(18-F). The minimal femoral artery diameter was 8.17 +/- 1.14 mm, and the calcification (0 to 3) and tortuosity scores (0 to 3) were 0.58 +/- 0.72 and 0.28 +/- 0.53, respectively. The mean sheath diameter was 8.10 +/- 0.82 mm, and the mean SFAR was 0.99 +/- 0.16. Vascular complications occurred in 27.6% (VARC major: 17.3%, minor: 10.2%), and major vascular complications predicted 30-day mortality (22.7% vs. 7.6%, p = 0.049). The SFAR (hazard ratio [HR]: 186.20, 95% confidence interval [CI]: 4.41 to 7,855.11), center experience (HR: 3.66, 95% CI: 1.17 to 11.49), and femoral calcification (HR: 3.44, 95% CI: 1.16 to 10.17) predicted major complications by multivariate analysis. An SFAR threshold of 1.05 (area under the curve = 0.727) predicted a higher rate

of VARC major complications (30.9% vs. 6.9%, p = 0.001) and 30-day mortality (18.2% vs. 4.2%, p = 0.016).\n\nConclusions Vascular complications in transfemoral TAVI are relatively frequent. VARC major vascular complications increase 30-day mortality and are predicted by experience, femoral calcification, and SFAR. Routine application of SFAR will improve patient selection for transfemoral EPZ5676 solubility dmso TAVI and may improve outcome. (J Am Coll Cardiol Intv 2011;4:851-8) (C) 2011 by the American College of Cardiology Foundation”
“Al-doped ZnO (AZO) films of similar to 100 nm thickness with various Al doping were prepared at 150 degrees C by atomic layer deposition on quartz Ro-3306 in vivo substrates. At low Al doping, the films were strongly textured along the [100] direction, while at higher Al doping the films remained amorphous. Atomic force microscopy results

showed that Al-O cycles when inserted in a ZnO film, corresponding to a few atomic percent Al, could remarkably reduce the surface roughness of the films. Hall measurements revealed a maximum mobility of 17.7 cm(2)/V s. Film resistivity reached a minima of 4.4 X 10(-3) Omega cm whereas the carrier concentration reached a maxima of 1.7 X 10(20) cm(-3), at 3 at. % Al. The band gap of AZO films varied from 3.23 eV for undoped ZnO films to 3.73 eV for AZO films with 24.6 at. % Al. Optical transmittance over 80% was obtained in the visible region. The detrimental impact of increased Al resulting in decreased conductivity due to doping past 3.0 at. % is evident in the x-ray diffraction data, as an abrupt increase in the optical band gap and as a deviation from the Burstein-Moss effect. (C) 2010 American Institute of Physics. [doi:10.1063/1.