S- 1 plus CDDP ended up being administrated for 30 months. S-1 and SOX were administered after progressive results, but he died 48 months after diagnosis. We report 2 cases of recurrent and advanced gastric disease with lasting survival because of effective chemotherapy.The patient ended up being 75-year-old male, he’s got already been diagnosed as ascending a cancerous colon resected by rt. hemicolectomy in September 2010. Last diagnosis was tub2, T4b, N1, Cy1, M0, pStage Ⅲc. Despite adjuvant chemotherapy, a lung metastasis ended up being present in April 2012, and it ended up being treated by thoracoscopic partial lung resection. In July 2012, pelvic lymph node recurrence ended up being found, and addressed by radiation therapy. In August 2013, appropriate testicular metastasis was resected. After a couple of years chemotherapy no-cost intervals, it absolutely was started again by S-1→irinotecan(CPT-11)→regorafenib due to peritoneal disseminations. In July 2016, transverse colostomy was carried out because of obstruction due to peritoneal dissemination. Although, chemotherapy had been proceeded after surgery by trifluridine plus bevacizumab(Bev)→CPT-11, recurrent tumor in rt spermatic cord was enlarged, which resected to cut back its discomfort. While continuing chemotherapy with CPT-11 plus Bev, fast growth of peritoneal disseminated tumor using its rapture has caused peritonitis and sepsis, so that it ended up being Malaria immunity obligated to be resected by concerning colon, ileum, and ureter in February 2019. Finally, with totally 6 times these businesses, continuing chemotherapy may be maintaining his QOL and prognosis.We practiced 3 cases of top gastric disease who underwent BillrothⅠ reconstruction in laparoscopy assisted subtotal gastrectomy. Two situations were feminine and 1 was male. The postoperative training course had been uneventful in most situations without heartburn, therefore the medical margin had been negative. The human body fat loss rate was 5.8-12.6%, in addition to short-term outcomes were fairly appropriate. Even though number of instances ACP-196 in this study had been tiny, repair with BillrothⅠ/delta-shaped anastomosis after laparoscopy assisted subtotal gastrectomy were considered to be useful.The client was a 60′s guy, whose main issues were melena and weight reduction. He visited our medical center, and additional evaluation revealed rectal cancer(Ra)invading the abdominal wall with multiple liver metastases. The clinical analysis ended up being cT4b(abdominal wall)N2bM1a(H1), cStage Ⅳ. We performed a transverse colostomy on the day just before chemotherapy administration. He had been administered 8 programs of FOLFOXIRI plus bevacizumab. Following the chemotherapy, the primary cyst and liver metastases revealed PR, with an analysis of ycT3N1bM1a(H1), Stage Ⅳ. We performed a robot-assisted laparoscopic reasonable anterior resection for the main cyst. Two months later on, the limited resection of liver S6 and S8 was carried out. The patient happens to be cancer-free for six months now.We investigated 34 cases of preoperative chemoradiotherapy(CRT)for locally higher level pancreatic cancer including resectable pancreatic cancer tumors in our division in the past 11 many years. For resectable(R)or borderline resectable(BR)pancreatic disease, survival curves had been generally speaking higher into the CRT plus S-1 group treated after CRT compared to the CRT team addressed with post-CRT chemotherapy, but there was no statistically significant difference. In non-resected situations, regional exacerbation was seen, that was one of several factors behind a decline in terminal QOL. Through the overhead, at the moment, it’s desirable to remove roentgen or BR pancreatic cancer after CRT, however the significance of surgery may improvement in the long run as a result of the improvement of multidisciplinary treatment.The patient ended up being a 43-year-old premenopausal woman with a 14×11 mm cyst in top outer quadrant of the left breast, identified as a fibroepithelial lesion using core needle biopsy. Resection was done. Histopathologically, the resected specimen had been identified as a fibroadenoma with lobular carcinoma in situ(LCIS). Tamoxifen ended up being administered as endocrine treatment to reduce recurrence risk. We report an instance of LCIS unintentionally found by surgical resection of a benign tumor.A 64-year-old girl had been labeled our medical center for treatment of pancreatic head disease with severe pancreatitis due to iatrogenic injury associated with the pancreatic duct during endoscopic retrograde cholangiopancreatography. In addition to a 28 mm pancreatic mind cyst, smooth muscle shadow and substance collection surrounding the superior mesenteric artery(SMA)due to pancreatitis were seen in the abdominal CT scan. The tumefaction had been histologically diagnosed as adenocarcinoma by endoscopic ultrasound-guided good needle aspiration. Neoadjuvant chemotherapy with gemcitabine and S-1 had been carried out to regulate the progression of this pancreatic cancer and improve the inflammatory modifications Risque infectieux for reduction of the operative risk. After 2 programs of neoadjuvant chemotherapy, abdominal CT scan revealed stable illness in accordance with the Response Evaluation Criteria in Solid Tumors and attenuation of this inflammatory changes surrounding the SMA. Then, subtotal stomach- protecting pancreaticoduodenectomy was performed with no trouble of peeling around the SMA regardless of the old inflammatory changes. Histological study of the resected specimen showed R0 resection. The patient had been released 18 times after surgery with no complications and it is surviving 9 months postoperatively with no recurrence. Neoadjuvant chemotherapy was helpful for infection control and enhancement associated with the inflammatory changes.A 68-year-old guy having a descending cancer of the colon with multiple metastases all the way to 9.5 cm in the correct lobe associated with liver(T3, N0, M1a)underwent laparoscopic colon resection for anemia control. Chemotherapy with mFOLFOX6 plus Bmab had been administered postoperatively. Because this treatment had little result, FOLFIRI plus Pmab was started three months later on.