This paper describes a public health approach that combines a national surveillance program with epidemiologic, laboratory, and prevention research to address knowledge gaps in rates and risk factors for inhibitor development, and in knowledge and behaviors of patients and providers, in addition to screening and treatment practices. Published by Elsevier Inc.”
“Background: A strong, Ro-3306 cost consistent association between childhood irradiation

and subsequent thyroid cancer provides an excellent model for studying radiation carcinogenesis.\n\nMethods: We evaluated gene expression in 63 paired RNA specimens from frozen normal and tumour thyroid tissues with individual iodine-131 (I-131) doses (0.008-8.6 Gy, no unirradiated controls) received from Chernobyl fallout during childhood (Ukrainian-American cohort). Approximately this website half of these randomly selected samples (32

tumour/normal tissue RNA specimens) were hybridised on 64 whole-genome microarrays (Agilent, 4 x 44 K). Associations between I-131 dose and gene expression were assessed separately in normal and tumour tissues using Kruskal – Wallis and linear trend tests. Of 155 genes significantly associated with I-131 after Bonferroni correction and with >= 2-fold increase per dose category, we selected 95 genes. On the remaining 31 RNA samples these genes were used for validation purposes using qRT-PCR.\n\nResults: Expression of eight genes (ABCC3, C1orf9, C6orf62, FGFR1OP2, HEY2, NDOR1, STAT3, and UCP3) in normal tissue and six genes (ANKRD46, CD47, HNRNPH1, NDOR1, SCEL, and SERPINA1) in tumour tissue was significantly associated with I-131. PANTHER/DAVID pathway analyses demonstrated significant over-representation of genes coding for nucleic acid binding in normal and tumour tissues, and for p53, EGF, and FGF signalling pathways in tumour tissue.\n\nConclusion: The multistep process of radiation carcinogenesis

p38 MAPK signaling begins in histologically normal thyroid tissue and may involve dose-dependent gene expression changes.”
“Chronic obstructive pulmonary disease is now considered as a systemic disease originating in the lungs. The natural history of this disease reveals numerous extrapulmonary manifestations and co-morbidity factors that complicate the evolution of COPD. Recent publications have documented these systemic manifestations and co-morbidities and clarified somewhat the role of muscle dysfunction, nutritional anomalies, endocrine dysfunction, anaemia, osteoporosis and cardiovascular and metabolic disorders as well as lung cancer and psychological elements in this complex disease.